Dicorynamine and harmalan-N-oxide, two new β-carboline alkaloids from Dicorynia guianensis Amsh heartwood

Jean-Baptiste Say Anouhe , Augustin Amissa Adima (1) , Florence Bobelé Niamké (1) , Didier Stien (2) , Brise Kassi Amian (1) , Pierre-Alain Blandinières (3) , David Virieux (4) , Jean-Luc Pirat (4) , Seraphin Kati-Coulibaly (1) , Nadine Amusant (3)

1 INPHB - Groupe de recherche en Chimie des Eaux et des Substances Naturelles, Institut National Polytechnique Houphoue¨t Boigny, BP 1313 Yamoussoukro, Cote d’Ivoire
2 ICSN - Institut de Chimie des Substances Naturelles
3 UMR ECOFOG - Ecologie des forêts de Guyane
4 ICGM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier

The chemical investigations of Dicorynia guianensis heartwood led to the isolation of four new indole alkaloids for the first time in this plant. Compound (1) identified as spiroindolone 2',3',4',9'-tetrahydrospiro [indoline-3,1'pyrido[3,4-b]-indol]-2-one, and compound (3) described as nitrone 1-methyl-4,9-dihydro-3H-pyrido [3,4-b] indole 2-oxide and were isolated for the first time as natural products. ABTS antioxidant activity guided their isolation. (C) 2015 Phytochemical Society of Europe.

Mots clés: Dicorynia guianensis; Spiroindolone; ABTS antioxidant; Biogenesis

Mots clés: Nitrone

Domaines: Chimie

Jean-Baptiste Say Anouhe, Augustin Amissa Adima, Florence Bobelé Niamké, Didier Stien, Brise Kassi Amian, et al.. Dicorynamine and harmalan-N-oxide, two new β-carboline alkaloids from Dicorynia guianensis Amsh heartwood. Phytochemistry Letters, 2015, 12, pp.158-163. ⟨10.1016/j.phytol.2015.03.012⟩. ⟨hal-01152699⟩